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KMID : 0614620200760050261
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Korean Journal of Gastroenterology
2020 Volume.76 No. 5 p.261 ~ p.264
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Oxaliplatin-induced Sudden Hearing Loss in a Patient with Pancreatic Cancer
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Kim Sung-Bum
Kim So-Yeong
Kim Kook-Hyun
Kim Tae-Nyeun
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Abstract
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Oxaliplatin is a new generation of platinum derivatives used frequently to treat solid organ malignancies, including colorectal and ovarian cancer. Recently, an oxaliplatin-based chemotherapeutic regimen was adopted for advanced pancreatic cancer. Although oxaliplatin has extensive therapeutic potential, its use can be limited by significant adverse effects, particularly ototoxicity. This paper reports a rare case of irreversible unilateral hearing loss in a 48-year-old female that developed after the intravenous infusion of oxaliplatin during pancreatic cancer treatment. To the best of the authors’ knowledge, this is the second reported case of oxaliplatin-related ototoxicity in pancreatic cancer.
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KEYWORD
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Ototoxicity, Oxaliplatin, Chemotherapy, Pancreatic neoplasms
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